Curse of Revelation

The Curse of Revelation is an ideal and a Dangerous Ninjutsu that is said to have been passed down from the Generation of the Sage of the Eight Paths to the Gekko Family and Shimiza Clan. There Hand Signs that could activate the Jutsu is Rat → Ox → Monkey → Tiger → Dragon → Boar.

Ten Signs
There are 10 Signs that could result the destruction of the Five Great Shinobi Nations.
 * Ikkaku buries the entire Sunagakure.
 * Rau la Crescent destroys the Stone Monument and the Will of Stone.
 * Isomaru floods the entire Kirigakure.
 * Mataru demolishes the Will of Fire.
 * Nagur spreads the Germs known as the Kalakoruhaptoposis that First demolish the body cells of the Shinobi, followed by Hot and Cold Fleshes and then the Self Dentonation.
 * Yamata Bagu destroys Barriers in the Five Village Countries.
 * Charrubi destroys the entire Hokage Faces with Tailed Beast Bombs.
 * Fortress Gundam devours the women in the Kumogakure.
 * Cuba destroys the Walls of the entire Konohagakure.
 * Lernaean Hydra destroys the entire Five Great Shinobi Countries.

Secret Sign
There is the Secret Sign in Izumo that is the Tailed Beasts sealed within the Gekko Family.

Trivia

 * The Curse of Revelation refers to Book of the Revelation which is in the Bible.